The mTOR pathway, angiogenesis, and telomerase activity are three key pathways, each contributing to the survival of cancer cells and despite treatment, resistance to the anticancer drug. Activation of mTOR signalling can lead to the upregulation of angiogenic factors such as VEGF, promoting the formation of new blood vessels to support tumor growth and survival. Additionally, mTOR activation can influence telomerase activity, the enzyme responsible for maintaining length and promoting cellular immortality. Exploring the role of mTORC1, mTORC2 and mTORC3 in formation of persister cells will provide major insights for novel therapeutic intervention.
mTOR signaling
&
Telomere biology
Research Topic
Address:
Dr. Santosh Kumar Guru, Ph.D., Assistant Professor
Room: 64, Department of Biological Sciences (Pharmacology & Toxicology),
National Institute of Pharmaceutical Education and Research (NIPER), An Institute of National Importance,
Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, GOI.
Balanagar, Hyderabad, Telangana, India-500037