2025

1. Dharavath Anil, Kaur Sivkan, Mohan PV Drupad, Guru SK. Harnessing cuproptosis: a new avenue for targeted cancer therapies. Apoptosis. 2025 Sep 12.

Selected Publications

3. Nivedita Bhardwaj, Swathilakshmi S, Nancy Tripathi, Sanjay Kumar, Uma Ranjan Lal, Ravikanth G, Santosh Kumar Guru, and Shreyans K Jain. Mahamanalactone A, a new triterpenoid from Dysoxylum malabaricum bark: a case study for rapid identification of new metabolites via LC-HRMS profiling and database mining strategy. Natural Product Research. 2025; 39: 9, 2438-2443.

4. Sahil Arora, Bhagyshree Patra, Isha Dhamija, Santosh Kumar Guru, and Raj Kumar. 2-(4-Bromobenzyl) tethered 4-amino aryl/alkyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidines: design, synthesis, anticancer assessment via dual topoisomerase-I/II inhibition, and in silico studies. RSC Medicinal Chemistry. 2025; 16: 2, 907-926.

2024

1. Sanju Kumari, Bhavana Prathyusha, Essha Chatterjee, Nancy Tripathi, Sanheeta Chakrabarty, Nivedita Bhardwaj, Santosh Kumar Guru, Jac Fredo Agastinose Ronickom, and Shreyans K. Jain. Prioritization of the Secondary Metabolites for the Rapid Annotation Based on Liquid Chromatography-High Resolution Mass Spectrometry Assessment: Varanasine and Schroffanone from Murraya paniculata and Cytotoxic Evaluation. Journal of Proteome Research. 2024; 23: 11, 4940-4950.

2. Amandeep Thakur, Yi-Hsuan Chu, N Vijayakameswara Rao, Jacob Mathew, Ajmer Singh Grewal, Prabhita Prabakaran, Santosh Guru, Jing Ping Liou, Chun-Hsu Pan, and Kunal Nepali. Leveraging a rationally designed veliparib-based anilide eliciting anti-leukemic effects for the design of pH-responsive polymer nanoformulation. European Journal of Medicinal Chemistry. 2024; 273, 116507.

3. Rachana Yadav, Srushti Mahajan, Hoshiyar Singh, Neelesh Kumar Mehra, Jitender Madan, Nandkumar Doijad, Pankaj Kumar Singh, and Santosh Kumar Guru*. Emerging In Vitro and In Vivo Models: Hope for the Better Understanding of Cancer Progression and Treatment. Advanced Biology. 2024; 8: 6, 2300487.

4. Mousumi Deb, Hoshiyar Singh, Diksha Manhas, Utpal Nandi, Santosh Kumar Guru*, and Parthasarathi Das*. Development of di-arylated 1, 2, 4-triazole-based derivatives as therapeutic agents against breast cancer: synthesis and biological evaluation. RSC Medicinal Chemistry. 2024; 15:9, 3097-3113.

2023

1. Sachin Sharma, Kavya Chandra, Aliva Naik, Anamika Sharma, Ram Sharma, Amandeep Thakur, Ajmer Singh Grewal, Ashwani K Dhingra, Arnab Banerjee, Jing Ping Liou, Santosh Kumar Guru*, and Kunal Nepali*. Flavone-based dual PARP-Tubulin inhibitor manifesting efficacy against endometrial cancer. Journal of Enzyme Inhibition and Medicinal Chemistry. 2023; 38: 1, 2276665.

2. Bharat Goel, Harichander Reddy, Anjali Cholkar, Sanjeev Kumar, Santosh Kumar Guru, and Shreyans K. Jain. Isolation of a new cytotoxic colchinoid from Gloriosa superba roots. Natural Product Research. 2023; 37: 23, 3909-3914.

3. Biswajit Dey, Bharat Goel, Essha Chatterjee, Hoshiyar Singh, Shreyans Jain, and Santosh Kumar Guru*. Gloriosine induces cell cycle arrest by autophagic cell death through negative regulation of YAP transcriptional activity in non-small cell lung cancer Gloriosine is a potent alkaloid derivative having potent anticancer activity. Molecular Cancer Therapeutics. 2023; 22: 12.

4. Pratyush Pragyandipta, Ravi Kumar Pedapati, Praveen Kumar Reddy, Arnab Nayek, Rajesh Kumar Meher, Santosh Kumar Guru, Srinivas Kantevari, and Pradeep K Naik. Rational design of novel microtubule targeting anticancer drugs N-imidazopyridine noscapinoids: Chemical synthesis and experimental evaluation based on in vitro using breast cancer cells and in vivo using xenograft mice model. Chemico-Biological Interactions. 2023; 382, 110606

2022

1. Bharat Sahu, Nivedita Bhardwaj, Essha Chatterjee, Biswajit Dey, Nancy Tripathi, Bharat Goel, Manoj Kushwaha, Brijesh Kumar, Bikarma Singh, Santosh Kumar Guru, and Shreyans K. Jain. LCMS-DNP-based dereplication of Araucaria cunninghamii Mudie gum-resin: identification of new cytotoxic labdane diterpene. Natural Product Research. 2022; 36, 6207-6214.

2. Ram Sharma, Esha Chatterjee, Jacob Mathew, Sachin Sharma, N Vijayakameswara Rao, Chun-Hsu Pan, Sung-Bau Lee, Ashwani Dhingra, Ajmer S Grewal, Jing Ping Liou, Santosh K Guru*, and Kunal Nepali*. Accommodation of ring C expanded deoxyvasicinone in the HDAC inhibitory pharmacophore culminates into a tractable anti-lung cancer agent and pH-responsive nanocarrier. European Journal of Medicinal Chemistry. 2022; 240, 114602.

3. Bharat Goel, Biswajit Dey, Essha Chatterjee, Nancy Tripathi, Nivedita Bhardwaj, Sanjay Kumar, Santosh Kumar Guru, and Shreyans K Jain. Antiproliferative potential of gloriosine: A lead for anticancer drug development. ACS Omega. 2022; 7, 33, 28994-29001.

2021

1. Shruti Gamya Dash, Srinivas Kantevari, Santosh Kumar Guru, and Pradeep Kumar Naik. Combination of docetaxel and newly synthesized 9-Br-trimethoxybenzyl-noscapine improve tubulin binding and enhances antitumor activity in breast cancer cells. Computers in biology and medicine. 2021; 139, 104996.

2. Bharat Goel, Essha Chatterjee, Biswajit Dey, Nancy Tripathi, Nivedita Bhardwaj, Arun Khattri, Santosh Kumar Guru, and Shreyans K Jain. Identification and Evaluation of Apoptosis-Inducing Activity of Ipomone from Ipomoea nil: A Novel, Unusual Bicyclo[3.2.1] Octanone Containing Gibberic Acid Diterpenoid. ACS Omega. 2021; 6 :12, 8253-8260 .

3. Anindita Ghosh, Rituparna Roy, Essha Chatterjee, Biswabandhu Bankura, Santosh Guru, and Chinmay Kumar Panda. Induction of apoptosis in human bladder cancer cells by triterpenoids isolated from Holarrhena antidysenterica through differential reactive oxygen species generation. Natural Product Research. 2021; 35, 24, 5629-5636.

2012-2018

1. Sanjoya S, Santosh Guru, Ameer L. Elaimy, John J. Amante, Jianhong Ou, Jun Yu, Lihua J. Zhu, and Arthur M. Mercurio. IMP3 stabilization of WNT5B mRNA facilitated TAZ activation in breast cancer. Cell reports, 2018; 23:9, 2559-2567.

2. Ameer L. Elaimy, Santosh Guru, Cheng Chang, Jianhong Ou, John J. Amante, Lihua Julie Zhu, Hira Lal Goel, and Arthur M. Mercurio. VEGF–neuropilin-2 signaling promotes stem-like traits in breast cancer cells by TAZ-mediated repression of the Rac GAP β2-chimaerin, Science signaling, 2018; 11:528, eaao6897.

3. Sandip B. Bharate, Vikas Kumar, Shreyans K. Jain, Mubashir J. Mintoo, Santosh K. Guru, Vijay K. Nuthakki, Mohit Sharma, Sonali S. Bharate, Sumit G. Gandhi, Dilip M. Mondhe, Shashi Bhushan, and Ram A. Vishwakarma. Discovery and preclinical development of IIIM-290, an orally active potent cyclin-dependent kinase inhibitor, Journal of Medicinal Chemistry, 2018; 61: 4, 1664-1687.

4. Rammohan R. Yadav*, Santosh K. Guru*, Prashant Joshi, Girish Mahajan, Mubashir J. Mintoo, Vikas Kumar, Sonali S. Bharate, Dilip M. Mondhe, Ram A. Vishwakarma, Shashi Bhushan, and Sandip B. Bharate. 6-Aryl substituted 4-(4-cyanomethyl) phenylamino quinazolines as a new class of isoform-selective PI3K-alpha inhibitors, European Journal of Medicinal Chemistry; 2016; 122: 731-743.

5. Anup S. Pathania, Santosh K. Guru, Suresh Kumar, Ashok Kumar, Masoor Ahmad, Shashi Bhushan, Parduman R. Sharma, Priya Mahajan, Bhahwal A. Shah, Simmi Sharma, Amit Nargotra, Ram Vishwakarma, Hasan Korkaya, and Fayaz Malik. Interplay between cell cycle and autophagy induced by boswellic acid analogue, Scientific Reports, 2016; 6: 1, 33146.

6. Aashiq Hussain, Asif Khurshid Qazi, Nagaraju Mupparapu, Santosh Kumar Guru, Ashok Kumar, Parduman Raj Sharma, Shashank Kumar Singh, Paramjit Singh, Mohd Jamal Dar, Sandip B Bharate, Mohmmad Afzal Zargar, Qazi Naveed Ahmed, Shashi Bhushan, Ram A Vishwakarma, and Abid Hamid. Modulation of glycolysis and lipogenesis by novel PI3K-selective molecule represses tumor angiogenesis and decreases colorectal cancer growth, Cancer Letters, 2016; 374: 2, 250-260.

7. Santosh Kumar Guru*, Anup Singh Pathania, Suresh Kumar, Deshidi Ramesh, Manjeet Kumar, Satinder Rana, Ajay Kumar, Fayaz Malik, PR Sharma, BK Chandan, Sundeep Jaglan, JP Sharma, Bhahwal Ali Shah, Sheikh Abdullah Tasduq, Surinder K Lattoo, Abdul Faruk, AK Saxena, RA Vishwakarma, and Shashi Bhushan. Secalonic acid-D represses HIF1α/VEGF-mediated angiogenesis by regulating the Akt/mTOR/p70S6K signaling cascade. Cancer Research, 2015; 75; 14; 2886-2896.

8. Suresh Kumar, Santosh Kumar Guru, Anup Singh Pathania, Sudhakar Manda, Ajay Kumar, Sandip B. Bharate, Ram A. Vishwakarma, Fayaz Malik, and Shashi Bhushan. Fascaplysin induces caspase-mediated crosstalk between apoptosis and autophagy through the inhibition of the PI3K/AKT/mTOR signaling cascade in human leukemia HL-60 cells; Journal of Cellular Biochemistry, 2015; 116:6, 985-997.

9. Anup S. Pathania, Zahoor A. Wani, Santosh K. Guru, Suresh Kumar, Shashi Bhushan, Hasan Korkaya, Darren F. Seals, Ajay Kumar, Dilip M. Mondhe, Zabeer Ahmed, Bal K. Chandan, and Fayaz Malik. The anti-angiogenic and cytotoxic effects of the boswellic acid analogue BA145 are potentiated by autophagy inhibitors, Molecular Cancer, 2015; 14:1.

10. Pathania, S Kumar, S Guru, F Malik, S Bhushan, A Kumar. The synthetic tryptanthrin analogue suppresses STATs signaling and induces caspase-dependent apoptosis via ERK upregulation in human leukemia HL-60 cells. EUROPEAN JOURNAL OF CANCER. 2014; 50: S141-S141.

14. Anup S Pathania, Amit Joshi, Suresh Kumar, Santosh K Guru, Shashi Bhushan, Parduman R Sharma, Wajid W Bhat, Ajit K Saxena, Jaswant Singh, Bhahwal A Shah, Samar S Andotra, Subhash C Taneja, Fayaz A Malik, and Ajay Kumar. Reversal of boswellic acid analog BA145-induced caspase-dependent apoptosis by PI3K inhibitor LY294002 and MEK inhibitor PD98059. Apoptosis, 2013; 18:12, 1561-1573

12. Shreyans K Jain, Surjeet Singh, Anamika Khajuria, Santosh K Guru, Prashant Joshi, Samdarshi Meena, Janhavi R Nadkarni, Amarinder Singh, Sonali S Bharate, Shashi Bhushan, Sandip B Bharate, Ram A Vishwakarma. Pyrano-isochromanones as IL-6 inhibitors: synthesis, in vitro and in vivo antiarthritic activity. Journal of Medicinal Chemistry, 2014; 57:16, 7085-7097.

13. Baljinder Singh, Santosh K. Guru, Smit Kour, Shreyans K. Jain, Rajni Sharma, Parduman R. Sharma, Shashank K. Singh, Shashi Bhushan, Sandip B. Bharate, and A. Vishwakarma. Synthesis, antiproliferative, and apoptosis-inducing activity of thiazolo [5, 4-d] pyrimidines. European Journal of Medicinal Chemistry, 2013; 70: 864-874.

11. G Lakshma Reddy, Santosh Kumar Guru, M Srinivas, Anup Singh Pathania, Priya Mahajan, Amit Nargotra, Shashi Bhushan, Ram A Vishwakarma, Sanghapal D Sawant. Synthesis of 5-substituted-1H-pyrazolo [4, 3-d] pyrimidin-7 (6H)-one analogs and their biological evaluation as anticancer agents: mTOR inhibitors. European Journal of Medicinal Chemistry, 2014; 80: 201-208.

15. S Kumar, SK Guru, AS Pathania, A Kumar, S Bhushan, F Malik. Autophagy triggered by magnolol derivative negatively regulates angiogenesis. Cell death & disease, 2013; 04:10, e889-e889.

16. Suresh Kumar, Ajay Kumar, Anup Singh Pathania, Santosh Kumar Guru, Srinivas Jada, Parduman Raj Sharma, Shashi Bhushan, Ajit Kumar Saxena, HM Sampath Kumar, Fayaz Malik. Tiron and trolox potentiate the autophagic cell death induced by magnolol analog Ery5 by activation of Bax in HL-60 cells. Apoptosis. 2013; 18:05, 605-617.

17. Kakkar Vandita, Bhushan Shashi, Kumar Guru Santosh, Kaur Indu Pal. Enhanced apoptotic effect of curcumin-loaded solid lipid nanoparticles. Molecular pharmaceutics, 2012; 09:12, 3411-3421

18. Debabrata Chanda, Shashi Bhushan, Santosh K. Guru, Karuna Shanker, Z. A. Wani, B. BA Rah, Suaib Luqman, Dilip M. Mondhe, Anirban Pal, and Arvind S. Negi. Anticancer activity, toxicity, and pharmacokinetic profile of an indanone derivative. European Journal of Pharmaceutical Sciences. 2012; 47:05, 988-995.

2. Essha Chatterjee, Ram Sharma, Biswajit Dey, Hoshiyar Singh, Aliva Naik, Anjesh Khan, Santanu Basak, Ankush Bansode, Ritika Sachdeva, Anamika Sharma, Rahul Kumar, Pradeep Naik, Pankaj Kumar Singh, Kunal Nepali, and Santosh Kumar Guru*. Anticancer activity of RM-3-22: a TAZQ-based hydroxamic acid derivative targeting NSCLC in vitro and in vivo. Frontiers in Pharmacology. 2025; 16, 1544666